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Several ongoing medicinal chemistry campaigns are focused on dual targeting of AMYR and GLP-1R (Gabery et al., 2025), with some candidates advancing to clinical trial phases (e.g., Novo Nordisk’s amycretin currently in phase 1b/2a clinical trials) (Dahl et al., 2025)
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However, despite its promising therapeutic effects, the use of HGF protein is limited by its poor bioavailability
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