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According to the National Institutes of Health Office of Dietary Supplements the below mentioned drugs may possibly interact with vitamin B12 injections: Chloramphenicol, an antibiotic Metformin, a drug for diabetes Proton pump inhibitors that are used for acid reflux, including omeprazole (Prilosec), lansoprazole (Prevacid) or esomeprazole (Nexium) Histamine H2 receptor agonists, which are a class of antacid and peptic ulcer drugs including Zantac, Pepcid and Tagamet Some anti-seizure drugs such as primidone, phenytoin and Phenobarbital Chemotherapy drugs Bile acid sequestrants such as cholestyramine and colestipol that reduces cholesterol Colchicine that helps in treating gout Tetracycline, which is an antibiotic Always tell your physician who has prescribed injections of vitamin B12 before taking any new drug