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These novel findings are complemented by the demonstration of reduced GPx1 in the colon of mice with DSS-induced colitis [41, 42], murine colitis induced by knockout of GPx1 and GPx2 [43], and genome-wide association studies that note polymorphisms in antioxidant genes, including GPxs in IBD [44, 45]

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Results Validation of Transfection of GSTP1 in HepG2 Cells To evaluate the role of GSTP1 in protecting against QIs-induced cellular perturbations, HepG2 cells were transiently transfected with a DNA construct containing the human GSTP1 cDNA behind a CMV-promoter

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