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In contrast, excessive Se intake or environmental exposure was associated with an increased risk for type 2 diabetes, neurodegenerative diseases (amyotrophic lateral sclerosis and Parkinson’s disease), and increased risk and mortality from some malignancies (carcinoma of prostate, buccal cavity, pharynx, stomach, colon, rectum, lungs, kidney, and urinary bladder, melanoma, multiple myeloma, lymphoid neoplasms, etc.) (43, 49, 50)