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At the same time, blood viscosity is abnormally increased in SCD due to decreased sickle RBC deformability, increased adhesion, and abnormal vasoreactivity, such that excessive increases in hemoglobin concentration may lead to viscosity-related complications
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While many growth factor systems have been examined as potential therapeutic targets for PD one that has been largely, and we think mistakenly, overlooked is the hepatocyte growth factor (HGF)/c-Met (its type I tyrosine kinase-receptor) system
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