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361 Covalent binding strategy Covalent inhibitors are a class of small-molecule compounds that form stronger bonds with the amino acid residues of specific proteins through covalent interactions, thereby increasing their inhibitory activity
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Many drugs have been repurposed as metabolic inhibitors or activators, like tigecycline (a known antibiotic) which can inhibit mitochondrial protein translation leading to inhibition of OxPhos (49, 104)
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