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In search of a pan-coronavirus vaccine: next-generation vaccine design and immune mechanisms | Cellular & Molecular Immunology
The NTS, includes three N-terminal amino acid residues and is characterized by the presence of His in the third position 24
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For example, studies with a short helical peptide derived from RNase A only exhibited helical character at the pH in which a protonated His residue at the i position interacts with the Glu carboxylate at the i+4 position, effectively stabilizing one helical turn
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