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At-risk groups include vegans and vegetarians (since most dietary sources of vitamin B12 are animal products), or people whose bodies may not absorb enough of the vitamin due to: Age (60+) Gastrointestinal diseases (like Crohn’s, ulcerative colitis, or celiac disease) Pernicious anemia Bariatric surgery Long term use of proton-pump inhibitors or H2 blockers “If people in these groups have noticed a change in their mood recently, they may want to investigate B12,” says Begdache