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Bioinformatics analysis of data sourced from the National Center for Biotechnology Information (NCBI) database revealed that beyond the increased F/B (Firmicutes/Bacteroides) ratio of CKD patients compared to the healthy control, there is an increased abundance of bacteria closely associated with kidney impairment in the CKD group, including Ralstonia and Porphyromonas which are known to correlate negatively with estimated glomerular filtration rate (eGFR) and may serve as markers of CKD progression (Liu W