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Opioid-induced microglial activation has been shown to oppose opioid analgesia and enhance tolerance, whereas inhibition or absence of this activation attenuates tolerance development [221,222]
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Of note, the extent of the demonstrated beneficial effect on recovery of muscle function and integrity is considerable, and involves the transection- (15, 37) crush- (16, 17) lesion of striated muscle, and healing impairment induced by systemic corticosteroid application (16), as well as function impairment induced by centrally acting agents (74, 75)
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