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More recently, p21-targeting models such as P21-3MR [38] and P21-Cre [39] have reinforced the central role of p21-mediated senescence in ageing and disease, with p21 depletion proving protective in these settings

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Participants achieved weight reductions of up to 15.1% at 32 weeks —approximately 40% greater than cagrilintide monotherapy results [6]