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Pre-operative use – reducing salivary, tracheobronchial, and gastric secretions, and blocking cardiac vagal reflexes during induction and intubation Protection during cholinergic reversal – blocking the peripheral muscarinic effects, such as bradycardia and secretions, of physostigmine, neostigmine, and pyridostigmine Radiologic imaging – improving visibility of the kidneys during a radiologic examination Biliary and renal colic – adjunctive use with a narcotic analgesic for symptomatic relief Those reversal agents are given to reverse curariform neuromuscular blockers, so the setting is almost always an operating room or a recovery unit

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For instance, in a murine model, Hofmann et al