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Non-Surgical Treatments Oral Medications While evidence is limited, some oral therapies may help in the early stages: Anti-inflammatory medications Vitamin E supplementation Pentoxifylline for improving blood flow Intralesional Injection Therapy Xiaflex (collagenase) – The only FDA-approved non-surgical treatment for Peyronie’s disease, administered in office cycles Verapamil injections – May help reduce plaque formation and improve curvature Steroid injections – Can reduce inflammation and pain during the acute phase Mechanical Therapy Penile traction devices – May help improve length and reduce curvature when used consistently Vacuum erection devices – Can help maintain penile health and potentially reduce progression Surgical Treatments For men with stable disease causing significant functional impairment, surgical intervention may be recommended: Penile Plication Shortening the longer side of the penis to correct curvature Preserves erectile function with minimal complications Best suited for men with good erectile function and adequate penile length Incision and Grafting Lengthening the curved side by incising the plaque and placing a graft Preserves penile length but carries higher risks May be combined with penile implant placement Penile Implant Surgery Recommended for men with both Peyronie’s disease and erectile dysfunction Can correct curvature while restoring erectile function May involve additional procedures to optimize penile straightening Advanced Treatment Options St

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In the mitochondria, small amounts of ROS are generated as by-products of oxidative phosphorylation