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X-ray data collection Diffraction data were collected mainly using automated X-ray centring and data collection at 100 K at I03 beamline, Diamond Light Source (Didcot, UK), with an X-ray wavelength of 0.976 Å

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In this model, moderate increases in pulmonary neutrophilia are expected and were indeed observed in IL-33-treated mice ( Figures 2I, J ), however the degree of increase in neutrophil populations was markedly lower in mice receiving melatonin +/- Luzindole alongside IL-33 ( Figures 2I, J )