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The presence of FAD-binding region and transmembrane hemes enable NOXs to act as an electron-transportation chain that transfers two electrons from cytosolic NADPH to extracellular O 2 , resulting in the generation of O 2 โ
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Supporting this notion, wildtype mice injected with Aฮฒ oligomers exhibit both depressive-like behaviors and microglial activation in the cortex and hippocampus, as well as aberrant TNF-ฮฑ signaling (Ledo et al., 2013
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