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In contrast, M-CuP showed negligible binding to either target, with maximal responses below 5 response units (RU) across all tested concentrations, confirming the essential role of multivalent architecture in cooperative target engagement
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Examples include CD95 (Fas) and TNF-related apoptosis-inducing ligand (TRAIL)-receptor (TRAIL-R) that are activated by their ligands, Fas ligand (FasL) and TRAIL, present on NK cell membranes or secreted by NK-derived exosomes
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