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As a border collie mix, Yuki may also have been a carrier for intestinal cobalamin (B12) malabsorption, the genetic mutation originally found in border collies
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However, in humans, proline has been known to be catalyzed by proline oxidase (POX), being regulated by age or by the peroxisome proliferator-activated receptor gamma (PPARγ) regulator [132,133,134,135]
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