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the present disclosure provides a method of reducing fat mass regain in a subject in a subject after the subject discontinues treatment with a GLP-1 receptor agonist, wherein the method comprises administering to the subject a myostatin-selective inhibitor (e.g., any one of the myostatin-selective antibodies or the antigen-binding fragments disclosed herein) in an amount effective to reduce fat mass gain as compared to a subject who has discontinued treatment with a GLP-1 receptor agonist but is not treated with the myostatin- selective inhibitor

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Thus, autoantibody testing is necessary for establishing the MG subtype